We're only entering the third week of the NFL season and injuries are already a major concern for several big-name players. Dalvin Cook (hamstring), Joe Mixon (knee) and Jay Ajayi (back) will all mi s Sunday's action due to injuries. The latest NFL odds for Week 3 reflect these absences and others as bettors react. The Eagles, who will have Corey Clement as their lead back, are now full Mike Hoffman Men Jersey touchdown favorites at home over the Colts, who will be without TE Jack Doyle (hip) and RB Marlon Mack (foot, hamstring). And the Jaguars are now 10-point favorites, after opening at -6.5, over the Titans, who could be without quarterback Marcus Mariota in this AFC South showdown. With so much uncertainty and so many NFL odds on the move, you'll want to see the NFL picks and predictions from SportsLine's advanced computer model.SportsLine's proprietary computer model went 176-80 last season and beat over 95 percent of CBS Office Pool players in 2016 and '17. It also performed better than 98 percent of experts tracked by NFLPickWatch.com during that span. Additionally, it went 48-34 on A-rated picks against the spread last season, and $100 bettors who followed it the past two seasons are up nearly $4,000. It also nailed its three top-rated picks in Week 2, including backing the against the spread (+4.5) and on the money line (+170) in their big upset of the . Now it has simulated every snap of Week 3 of the Owen Tippett Men Jersey 2018 NFL season 10,000 times and its Week 3 NFL picks are in. One Week 3 NFL pick the model is all over: The (-7) roll over the in a battle for Los Angeles. The Chargers, powered by three touchdowns from , easily took care of the in Week 2. But the completion steps up in a big way against the Rams, who have outscored opponents 67-13 and are focused on a Super Bowl run. The Rams held Cardinals quarterback under 100 yards on 27 attempt and limited to just 48 yards.The model says will throw for over 250 yards, while has a strong chance to record 100 yards on the ground as the Rams cover the spread in almost 55 percent of simulations. The model is also calling Aleksi Heponiemi Women Jersey for 45 total points to be scored, clearing the under (48) with room to spare. Another one of the top Week 3 NFL picks you can make with confidence: the Giants (+6) cover on the road at Houston.Both teams are 0-2 straight-up and against the spread, but have plenty of firepower on offense, even if their records have been lackluster so far. The Giants came within five points of beating the Jaguars in Week 1 and have dynamic rookie Saquon Barkley, who has the longest run from scrimmage of any back this season at 68 yards. The Texans, meanwhile, came within a touchdown of beating the Patriots two weeks ago. Brett Connolly Jersey The line on this game opened at Texans -3.5, but has since grown by 2.5. SportsLine's model says that's too much for a Houston team that's averaging fewer than 20 points per game and lost to the Blaine Gabbert-quarterbacked Titans last week. New York covers in 54 percent of simulations, and the model also says there's plenty of value on the Giants' money line (+220). The model also has a strong pick you need to see for the huge battle between the Chiefs and featuring and , and is calling for a team with postseason aspirations to get shocked at home by an underdog. What NFL picks can you make with confidence in Week 3? And what favorite goes down hard? Check out the latest NFL odds below and then . Buffalo Bills at (-16.5, 41.5) at (-3, 44.5) at (-2, 53.5) at (-6, 46.5) at (-6, 42.5) at (-3, 44.5) at (-7, 46) at (-10, 40) San Francisco 49ers at Kansas City Chiefs (-6.5, 55) at (+2.5, 45) Los Angeles Chargers at Los Angles Rams (-7, 48.5) at (+6, 38.5) at (-1.5, 40.5) at (+7, 54.5) Pittsburgh Denis Malgin Men Jersey Steelers at (+1, 54.5)